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Interrater agreement of Jadad's scale

Abstract

Jadad's scale is widely used to assess the quality of clinical trials. It's a five questions scale composed of the following questions: 1) Is the study randomized? 2) Is the study double blinded? 3) Is there a description of withdrawals? 4) Is the randomization adequately described? 5) Is the blindness adequately ...

Uncertainty principle and cumulative meta-analysis

Abstract

A randomized clinical trial (RCT) is only justified if the requirements of the uncertainty principle (UP) are met. That is, a trial should only be conducted if we are uncertain which of the competing treatments would benefit the patient more. This ethical and scientific requirement mandates that before we conduct a trial, pre-existing knowledge ...

Bisphosphonates in multiple myeloma

Abstract

Multiple myeloma is a disease characterized by the neoplastic proliferation of a clone of plasma cells that can lead to bone destruction. Bisphosphonates are specific inhibitors of osteoclastic activity. Therefore, there is a pharmacological basis for their use in multiple myeloma. However, the exact clinical role of ...

Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism

Abstract

Low molecular weight heparins have been shown to be effective and safe for prevention of venous thromboembolism. There is accumulating evidence that these new anticoagulants are also effective and safe for treatment of venous thromboembolism. OBJECTIVES: The objective of this review was to determine the effect of ...

Optimal search strategy for clinical trials in the Latin American and Caribbean Health Science Literature database: an update

Keywords

Clinical Trials or Estudos Clínicos; Databases or Bases de Dados; Latin America or América Latina; Systematic Review or Revisão Sistemática; LILACS; Epidemiology or Epidemiologia; Evidence-Based Medicine or Medicina Baseada em Evidências;

Locating and appraising systematic reviews

Abstract:

To the Editor: In their recent article, Hunt and McKibbon (1) described the strengths and weaknesses of several methods of locating systematic reviews, including the use of such electronic databases as MEDLINE, EMBASE, Best Evidence, and the Cochrane Library.

Improving retrieval of clinical trials in the LILACS database.

Abstract

The Cochrane Collaboration has been working to re-tag articles in Medline as RANDOMIZED CONTROLLED TRIAL (RCT) and CONTROLLED CLINICAL TRIALS (CCT). The LILACS database has not previously been systematically searched to identify studies for re-tagging. This is the first effort to improve retrieval from this ...

Optimal search strategy for clinical trials in the Latin American and Caribbean Health Science Literature Database (LILACS)

Abstract

OBJECTIVE: To define and disseminate the optimal search strategy for clinical trials in the Latin American and Caribbean Health Science Literature (LILACS). This strategy was elaborated based on the optimal search strategy for MEDLINE recommended by Cochrane Collaboration for the identification of clinical trials in ...