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Natalizumab for Rapidly Evolving Severe Relapsing-Remitting Multiple Sclerosis (RESRRMS) Patients: 5-Year Budget Impact Analysis (BIA) from the Brazilian Public Payer Perspective

Abstract

Objectives: Multiple sclerosis (MS) is a neurodegenerative disease associated with long-term disability and significant economic impact. With the addition of new agents for the treatment of MS (e.g. natalizumab), there is a need to evaluate the relative value of newer therapies in terms of cost, given health care ...

Costs of HER 2 Negative, Hormonal Receptor Positive, Metastatic Breast Cancer (MBC-HR+) Treated with Everolimus (EVE) + Exemestane (EXE) in the Brazilian Private System (BPS): A Real World (RW) and Published Literature Analysis

Abstract

Objectives: EVE in association with aromatase inhibitor was recently approved by ANVISA (Brazilian Regulatory Agency) for MBC-HR+ patients. EVE redefines the role of endocrine therapy in MBC-HR+ reversing endocrine resistance. The aim of this study is to determine the costs associated to the introduction of EVE + EXE for ...

Cost-Effectiveness Analyses of Natalizumab for 1st Line Versus Interferon Beta-1a 44 Mcg in the Treatment of Highly Active Relapsing-Remitting Multiple Sclerosis Patients in Brazil

Abstract

Objectives: Multiple sclerosis (MS) is a neurologic disease that can dramatically affect the patient. The aim of this study is to conduct a cost-effectiveness analysis of natalizumab (Tysabri®) versus interferon beta-1a (IFNB1a) 44mcg (Rebif®) for treat- ing Highly Active Relapsing Remitting Multiple Sclerosis (HARRMS) ...

Costs of Hormonal Receptor Positive, Her 2 Negative Metastatic Breast Cancer (MBC-HR+) in Brazilian Private System (BPS): A Real World and Published Literature Analysis

Abstract

Objectives: Recently, MBC-HR+ was found to have a diverse pattern of response to the treatment compared to other MBC. Our aim is to determine the costs of treat- ment associated with this disease, from the perspective of BPS. MethOds: A large private database of medical claims for chemotherapy (Ch) (Evidencias Database) ...

Decision Tree Construction And Cost-Effectiveness Analysis Of Treatment Of Ulcerative Colitis With Pentasa Mesalazine 2g Sachet

Abstract

Unspecified Ulcerative Rectocolitis is a chronic disease that affects between 0.5 and 24.5/105 inhabitants in the world. National and international clinical guidelines recommend the use of aminosalicylates (including mesalazine) as first-line therapy for induction of remission of unspecified ulcerative rectocolitis, and ...

Enteral Diets (ED): A Cost-Comparison Analysis for In-Hospital Preparations Based on Real World Observation

Abstract

Objectives: ED can be administered based on three different systems – powder based (Po), open, liquid (Op), and a completely closed (Cl). There are differences in the preparation, installation and delivery and in the diarrhea rates among them. Our aim was to measure the total costs for each system, considering the ...

Update 2013: Cost-Effectiveness of Transcatheter Aortic-Valve Implantation for Severe Symptomatic Aortic Stenosis in Inoperable Patients in Brazilian Public Health Care System

Abstract 

Objectives: Aortic stenosis is the most common valvular heart disease in the elderly – its prevalence is estimated to be up to 5% in individuals over 75 years. Surgical replacement of the aortic valve is considered the standard care and in the absence of serious coexisting conditions, the procedure is associated with ...

Budgetary impact of oral chemotherapy incorporation in Brazil: a real world data analysis from the private payer perspective

Abstract

Background: In Brazil, health insurance companies (HIC) must, according to the law, offer coverage for intravenous chemotherapy drugs (IVChem), but not for oral chemotherapy drugs (OChem). We aimed to evaluate the incremental costs and the budgetary impact of the incorporation of OChem, using real world data, from the ...

Pseudomonas aeruginosa infection in patients with cystic fibrosis: scientific evidence regarding clinical impact, diagnosis, and treatment

Abstract

Evidence-based techniques have been increasingly used in the creation of clinical guidelines and the development of recommendations for medical practice. The use of levels of evidence allows the reader to identify the quality of scientific information that supports the recommendations made by experts. The objective of ...

Cost-Effectiveness of Cinacalcet Chronic Kidney Disease Patients on Dialysis with Secondary Hyperparathyroidism in Brazilian Public Health Care System (SUS)

Abstract

OBJECTIVES: Cinacalcet effectively reduces elevated levels of parathyroid hormone (PTH) in patients with CKD and consequently may reduce cardiovascular events, mortality and bone metabolism. This study assesses the cost-effectiveness of cinacalcet plus standard of care for the treatment of SHPT patients on dialysis compared ...