Efficacy Of Adjuvant Chemotherapy With Gemcitabine (GEM) Compared To Surgery-Only In Patients With Resected Pancreatic Cancer: Systematic Review (SR) And Meta-analysis (MA)


OBJECTIVES: We aimed to perform a systematic review (SR) with meta-analysis (MA) of all randomized controlled trials (RCT) comparing the efficacy of adjuvant chemotherapy with gemcitabine (GEM) versus observation in patients with resected pancreatic cancer. METHODS: Several databases were searched, including MEDLINE, EMBASE, LILACS, and CENTRAL. The ...

Update 2010: Efficacy Of Palonosetron (PAL) Compared To Other Serotonin Inhibitors (5-HT3R) In Preventing Chemotherapy-induced Nausea And Vomiting (CINV) In Patients Receiving Moderately Or Highly Emetogenic (MOHE) Treatment: An Update Of The Previously Published Systematic Review And Meta-Analysis


OBJECTIVES: To perform an update of the previously published systematic review and meta-analysis (Engel T. et al. ISPOR 2009) of all randomized controlled trials comparing a single intravenous dose of PAL 0.25 mg with other 5-HT3R in patients receiving MoHE chemotherapy. METHODS: Several databases were searched, including MEDLINE, EMBASE, LILACS, and ...

Ideal Vial Size For Bortezomib: Real World Data On Waste And Cost Reduction In Multiple Myeloma (MM)


OBJECTIVES: Single size vials of chemotherapy drugs may be a source of waste and increase in treatment costs. Bortezomib, a drug frequently used in MM treatments, is available in a 3.5mg vial (above the average dose commonly prescribed) without antimicrobial preservatives, making mandatory its administration within 8 hours of preparation. Through ...

Lead occupational exposure and health risks to workers


Lead is one of the main environmental contaminants and its role on the occupational setting has been studied for decades. The aim of this article is to provide an ample review on the theme, inclu- ding market, legislative and medical perspectives and also to present data from the main works on this field.

Evidence-based medicine as a tool to support judicial decisions - Medicina baseada em evidências como ferramenta para as decisões judiciais


Evidence-Based Medicine; budgetary impact; law; judiciary system; people's rights; economy; health; 

How to cite this article

Clark , O. (2010). Evidence-based medicine as a tool to support judicial decisions - Medicina baseada em evidências como ...

Environmental risk in Brazilian big cities


The ambient pollution in big cities is associated to an increase in morbidity and mortality of the po- pulation. In Brazil, there are some studies that have evaluated the association among many air pollu- tion and health outcomes. Our aim was to identify studies performed in the country that looked for an association between pollution and the health ...

Update 2010: Bisphosphonates in multiple myeloma


BACKGROUND: Bisphosphonates are specific inhibitors of osteoclastic activity and are currently used as supportive therapy for multiple myeloma (MM). However, the exact clinical role of bisphosphonates in MM remains unclear. OBJECTIVES: This update of the first review published in 2002. We have also analyzed observational studies targeting ...

Epidemiologic characteristics of renal cell carcinoma in Brazil


PURPOSE: In Brazil, National data regarding the epidemiology of renal cell carcinoma (RCC) are scarce. The aim of this study was to describe the demographic, clinical, and pathologic characteristics of RCC diagnosed and treated by members of the SBU - Brazilian Society of Urology. MATERIALS AND METHODS: For this cross-sectional study, data were ...

Real World Data On Multifraction (MFR) Versus Single Fraction (SFR) Radiotherapy To Treat Bone Metastasis: Impact In Costs For Private Health Care (PHC) Providers In Brazil


OBJECTIVES: There is available evidence from a systematic review with meta-analysis that MFR and SFR have comparative efficacy in the treatment of bone metastasis. We aimed to compare the costs of MFR (20 Gy in five applications or 30 Gy in ten applications) versus SFR in the treatment of bone metastasis and pain control and determine the budgetary ...

Intragastric Baloon (IGB) For Morbidly Obese (MOP) And Super Obese Patients (SOP) Systematic Review (SR) And Health Technology Assessment (HTA)


OBJECTIVES: To compile the body of evidence and produce a HTA on IGB in morbidly obese (MOP) and super obese (BMI ≥ 50) patients. To evaluate the impact on IGB on weight loss, co-morbidities (CM), reduction of post-operatory complications on bariatric surgery. METHODS: We performed a SR on Medline and Cochrane Library among other databases, ...